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Ex vivo TriPollar STOP at-home study (Journal of Dermatological Treatment, 2010): collagen remodeling

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Resultados clave

  • Published in the Journal of Dermatological Treatment (2010).
  • Ex vivo study on human skin from 8 donors.
  • +41% new collagen synthesis.
  • Dermal collagen recovery from 56.6% to 65.1% after UV aging.
  • Collagen remodeling in the superficial and mid dermis.

Resumen

Study published in the Journal of Dermatological Treatment (Boisnic S, Branchet MC. J Dermatolog Treat 2010;21:301-305) that analyzes in the laboratory how STOP, the TriPollar home-use radiofrequency facial device and predecessor of TriPollar Stop Vx2 and TriPollar Aura, acts on collagen.

Human skin samples from 8 donors were used, aged with UV radiation and subsequently treated with the device, to measure dermal collagen and new collagen synthesis.

Desarrollo del estudio

Methodology

  • Samples: human skin from 8 donors from 4 abdominoplasties and 4 cervicofacial liftings.
  • Groups: each sample was divided into three parts: untreated skin, aged skin with UVA and UVB, and aged skin treated for 5 minutes with STOP.
  • Variables: percentage of the dermis occupied by collagen with image analysis and amount of new collagen (Sircol Collagen Assay) after 10 days in culture.
  • Statistics: paired Student's t-test, p-value less than 0.05.

Results

  • UV aging reduced collagen in the superficial and mid dermis from 76.3% to 56.6%.
  • After treatment with STOP, collagen in the superficial and mid dermis increased to 65.1%, a significant recovery.
  • New collagen synthesis: +41% compared to untreated aged skin.
  • Histology showed remodeling of collagen fibers in the superficial and mid dermis.

Relationship with TriPollar Stop Vx2 and TriPollar Aura

This study explains the mechanism of TriPollar multi-radiofrequency for home use: controlled heat stimulates fibroblasts and the production of new collagen. TriPollar Stop Vx2 and TriPollar Aura evolve this technology and add DMA (Dynamic Muscle Activation).

Conclusiones

The study demonstrates that at-home TriPollar radiofrequency produces significant collagen remodeling, both in structure and quantity, with 41% more new collagen in the treated skin.

The results provide a biological explanation for the improvement in firmness and wrinkles observed in clinical studies with the at-home device.

TriPollar Stop Vx2 and TriPollar Aura complement the usual skincare routine and cosmetic and medical aesthetic treatments.